The move follows years of controversy about the issue and against a backdrop of heightened tensions in the US about racism.
The Simpsons is ending the use of white actors to voice black and ethnic minority characters, producers have said.
The move follows years of controversy about the issue and calls for greater diversity within the entertainment industry.
It also comes against a backdrop of heightened tensions in the US about racism, following mass protests over the killing of black Americans by police, sparked by the death of George Floyd.
In a statement, the Fox network, which broadcasts the show, said: “Moving forward, The Simpsons will no longer have white actors voice non-white characters.”
The Simpsons, which has been on the air since 1989 and is syndicated in more than 100 countries, had faced public pressure for years over for having Hank Azaria, who is white, voicing Indian shopkeeper Apu.