Nick Pivetta (4-6) took the loss despite striking out eight consecutive batters, tying a Red Sox record for the second time.
Lawrence Butler hit a two-run double to back a solid outing from JP Sears as the Oakland Athletics beat the Boston Red Sox 5-2 on Wednesday night.
Oakland improved to 1-4 this season against the Red Sox, who had won seven of eight overall.
Nick Pivetta (4-6) took the loss despite striking out eight consecutive batters, tying a Red Sox record for the second time. He also fanned eight straight Detroit Tigers on May 30.
The only other Red Sox pitcher to accomplish the feat was Roger Clemens, when he whiffed a record 20 total hitters against Seattle on April 29, 1986.
Pivetta went 6 2/3 innings for the Red Sox, giving up four runs on six hits and two walks.