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New strategy for the synthesis of axially chiral allenic compounds

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Recently, a Chinese research team led by Prof. Guo Chang at the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS) managed to catalyze an asymmetric propargyl substitution reaction with a nickel-derived catalyst, successfully synthesizing a series of chiral dienes in a diversified route.
Recently, a Chinese research team led by Prof. Guo Chang at the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS) managed to catalyze an asymmetric propargyl substitution reaction with a nickel-derived catalyst, successfully synthesizing a series of chiral dienes in a diversified route.

Their work was published in Nature Communications and Journal of the American Chemical Society.
Due to their unique structural characteristics, allenic compounds have been widely used in synthetic chemistry, pharmaceutical chemistry and materials science.

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