A team of scientists from the Chinese Academy of Sciences (CAS) and BGI Research has uncovered the intricate mechanisms by which immunoglobulins influence the aging process, a finding that might reshape our understanding of aging.
A team of scientists from the Chinese Academy of Sciences (CAS) and BGI Research has uncovered the intricate mechanisms by which immunoglobulins influence the aging process, a finding that might reshape our understanding of aging.
This research, published in Cell on Nov. 4, not only charts a high-precision map of aging across various organs but also reveals the dual-edged sword of immunoglobulins in systemic aging.
The quest for systemic biomarkers and key drivers of aging has been a long-standing puzzle in the field of gerontology. This study, a collaborative effort between Liu Guanghui’s team from the Institute of Zoology (IOZ) of CAS, Gu Ying’s team from BGI Research, Zhang Weiqi’s team from the Beijing Institute of Genomics of CAS, and Qu Jing’s team also from IOZ, has provided compelling answers.
By meticulously analyzing millions of spatial spots across nine organs in male mice, the team created high-precision spatial transcriptomic maps. These maps detailed the spatial distribution of more than 70 cell types, offering a vivid picture of aging’s spatial characteristics.
