An apparent suicide bomber targeted Supreme Court employees leaving their offices at the end of the working day, police at the scene said.
The Ministry of Health, which reported the casualty numbers, said the figure was expected to rise.
Reuters witnesses reported blood stains on the street and numerous ambulances leaving the area.
There was no immediate claim of responsibility.
(Reporting by Mirwais Harooni; Writing by Josh Smith; Editing by Robert Birsel)
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