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Matthew Perry was ‘angry and mean’ from testosterone shots in weeks before death: autopsy

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«Friends» actor Matthew Perry was getting testosterone injections before his death by ketamine, which a friend said left him «angry and mean,» according to his autopsy report.
Matthew Perry was getting regular injections of testosterone in the weeks leading up to his tragic death — which a friend said left him “angry and mean,” according to his autopsy report.
The male hormone was just one of many prescriptions the iconic “Friends” star had been taking when he accidentally drowned in his hot tub on Oct. 28, including ketamine, which officials ruled as the cause of his death.
Perry, 54, was undergoing frequent ketamine infusions to treat depression and drug addiction, though the medical examiner noted that the drug in his system could not have been from his final infusion.
How the actor got his hands on the tranquilizer is not clear, but a female associate asserted that Perry had been generally happy, despite irritability brought on by the testosterone treatments.
“She last spoke to [Perry] a few days ago, and he seemed fine and was in “good spirits,” the 29-page autopsy said of the unnamed woman.
According to the associate, Perry told her he would “never kill himself” and appeared hopeful for his future, even asking his doctors to wean him off ketamine and Buprenorphine, both used to treat drug addiction, after celebrating 19 months of reported sobriety.

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