A research group led by chemist Thomas Magauer has accomplished a divergent strategy to synthesize nine complex natural compounds. The developed method requires significantly less time and results in a variety of compounds with different structures and biological properties. The paper is published in the journal Angewandte Chemie International Edition.
A research group led by chemist Thomas Magauer has accomplished a divergent strategy to synthesize nine complex natural compounds. The developed method requires significantly less time and results in a variety of compounds with different structures and biological properties. The paper is published in the journal Angewandte Chemie International Edition.
Chemical synthesis enables the construction of complex molecules and active drug substances. Various strategies based on linear, convergent or divergent synthesis can be employed. For linear strategies, a target compound is synthesized from a single starting material, similar to building a house by assembling individual bricks. In contrast, convergent approaches are analogous to prefabricated houses, where smaller molecular units are linked together to form a larger molecule at a later stage of the synthesis. For both strategies, the target compound possesses the same molecular structure.
In nature, functionalization or rearrangement of a common molecular structures allows for the modification of the biological activity.
