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N.F.L. Week 1 Predictions: Our Picks Against the Spread

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Dueling Alabama quarterbacks and a rematch of January’s Browns-Chiefs playoff game make for a compelling start to the regular season.
It’s back. The N.F.L. regular season is upon us, with an additional 17th game for every team, and with some hard-earned certitudes. From now until February, the league will try its darnedest to again complete its schedule without interruption — from Covid-19, hurricanes, whatever — until Super Bowl LVI can be played at SoFi Stadium in Inglewood, Calif. What happens between now and then, though, is up to variables on and off the field. It’s fair to assume that only a handful of contenders have a shot at a championship, but what about as a week-to-week chaos agent? Well, that role could be filled by nearly any team. This week’s matchups include playoff rematches, the debuts of rookie quarterbacks and the returns of star players from injuries. Here’s a look at Week 1, with all picks made against the spread by a new columnist who takes over the duty for the 2021 season. Cleveland Browns at Kansas City,4:25 p.m., CBS Line: Chiefs -6| Total: 53 A rematch of last season’s A.F.C. divisional playoff gives new players on Cleveland and Kansas City the opportunity to show their value. Defensive end Jadeveon Clowney, a three-time Pro Bowl selection who is playing for his fourth team in four years, will try to pressure Patrick Mahomes. Kansas City’s upgraded offensive line — it has five new projected starters, including tackle Orlando Brown and guard Joe Thuney — looks to prevent jarring hits like the one in last season’s playoff game that sent Mahomes into the concussion protocol. Odell Beckham Jr.’s return from a knee injury will give Kansas City’s defense another threat to account for. But if Mahomes is well protected, it will be risky to bet against him. Pick: Kansas City -6 Green Bay Packers at New Orleans Saints (kinda),4:25 p.m., Fox Line: Packers -4| Total: 50 Hurricane Ida’s devastation in New Orleans caused this game to be relocated to Jacksonville, Fla., adding another disruption to teams whose off-seasons were full of them. The Packers and a disgruntled Aaron Rodgers finally settled their differences for perhaps one final try at a Super Bowl. The Saints, who have operated in Texas since late August, begin the post-Drew Brees era with Jameis Winston at quarterback. His test will be finding targets to carry the load of Michael Thomas, the team’s top receiver who is out for six weeks after having foot surgery in the off-season. The Packers have had roster continuity and have not dealt with similar logistical hurdles. Pick: Packers -4 Pittsburgh Steelers at Buffalo Bills,1 p.m., CBS Line: Bills -6.5| Total: 49 The Steelers deteriorated toward the end of last season while the Bills improved. Pittsburgh drafted Najee Harris in the first round to boost an abysmal rushing attack that netted only 3.6 yards an attempt, ranking last in the league. But quarterback Josh Allen’s ascent into being one of the league’s best players should continue with Buffalo’s addition of wide receiver Emmanuel Sanders to complement Stefon Diggs, who led the N.F.L. in receiving yards and catches last season. Bills fans should get their tables ready. Pick: Bills -6.5 Arizona Cardinals at Tennessee Titans,1 p.m., CBS Line: Titans -2.5| Total: 52 Julio Jones. Derrick Henry. A.J. Brown. The Cardinals’ defense will be the first unit to try to contain Tennessee’s new-look offense. Will it focus on stopping Henry and creep defenders close to the line of scrimmage? Will it double-team Jones and leave Brown in man coverage? Vice versa? Regardless of the strategy, Arizona will do so with a young linebacker corps and questions at cornerback after Patrick Peterson departed in free agency and his replacement, Malcolm Butler, retired during training camp. Even with J.J. Watt now on the edge, countering the Titans’ attack will be more than the Cardinals can handle so early in the season. Pick: Titans -2.5 Chicago Bears at Los Angeles Rams,8:20 p.m., NBC Line: Rams -7.5| Total: 45.5 The Rams and the Bears added veteran quarterbacks in the off-season and received different receptions from their fans. Los Angeles fans embraced Matthew Stafford as their hope to reach the Super Bowl, while the Bears faithful called unsuccessfully for Andy Dalton to be benched for the rookie Justin Fields.

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