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'Worm-on-a-chip' device could someday help diagnose lung cancer

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Dogs can use their incredible sense of smell to sniff out various forms of cancer in human breath, blood and urine samples. Similarly, in the lab a much simpler organism, the roundworm C. elegans, wriggles its way toward cancer cells by following an odor trail. Today, scientists report a device that uses the tiny worms to detect lung cancer cells. This « worm-on-a-chip » could someday help doctors noninvasively diagnose cancer at an earlier stage.
March 20,2022 Dogs can use their incredible sense of smell to sniff out various forms of cancer in human breath, blood and urine samples. Similarly, in the lab a much simpler organism, the roundworm C. elegans, wriggles its way toward cancer cells by following an odor trail. Today, scientists report a device that uses the tiny worms to detect lung cancer cells. This « worm-on-a-chip » could someday help doctors noninvasively diagnose cancer at an earlier stage. The researchers will present their results today at the spring meeting of the American Chemical Society (ACS). Early diagnosis of cancer is critical for effective treatment and survival, says Nari Jang, a graduate student who is presenting the work at the meeting. Therefore, cancer screening methods should be quick, easy, economical and noninvasive. Currently, doctors diagnose lung cancer by imaging tests or biopsies, but these methods often can’t detect tumors at their earliest stages. Although dogs can be trained to sniff out human cancer, they aren’t practical to keep in labs.

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