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iPS視細胞移植、失明マウスが光に反応 ヒト応用へ

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NewsHubiPS細胞から作った視細胞を失明したマウスの目に移植し、実際に光を感じさせることに理化学研究所の万代道子・副プロジェクトリーダーらが成功した。失明につながる難病の治療を目指し、2年以内に臨床研究を申請する計画だ。 米科学誌ステムセルリポーツに11日発表する。光は網膜の中の視細胞が感じ取り、脳につながる神経に信号を送る。視細胞は、信号を脳に伝える神経の層と、これらの活動を支える色素上皮細胞の層に挟まれ、体内で新たに作られないため、病気で壊れると視力を失う。 グループは、理研の笹井芳樹氏(故人)らが開発した、網膜を試験管内で作り出す技術を応用し、マウスのiPS細胞から未熟な状態の視細胞を作製。視細胞を失ったマウスに移植すると、目の中で成熟して正常な視細胞のようになることを突き止めていた。 今回、移植から1カ月以上たったマウスの目から網膜を取り出して調べると、視細胞が移植先の神経とつながり、光をあてると信号が流れることを確認。マウスの行動テストでも、約4割が光に反応することがわかった。 グループは次の段階として、ヒトのiPS細胞から作った視細胞の効果や安全性を動物で確認できれば、遺伝が原因で視細胞が壊れる網膜色素変性の患者で臨床研究を始める。万代さんは「移植がうまくいけば、病気の進行を遅らせたり、視力を部分的に回復させたりできる可能性がある」と話す。網膜色素変性は国内に約3万人の患者がいるとみられる。根治治療がなく、カメラで得た情報で神経を刺激する人工網膜や遺伝子治療が試みられている。 理研では、色素上皮が傷ついて物が見えづらくなる加齢黄斑変性の患者にiPS細胞から作った色素上皮を移植する臨床研究に着手し、2014年に世界初の手術に成功している。(阿部彰芳)

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How the original iPhone stacks up to the iPhone 7 Plus

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NewsHubEverything from the biggest tech show!
Our editors bring you complete coverage from the 2017 International CES, and scour the showroom floor for the hottest new tech gadgets around.

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The Strangest Scenes From CES 2017

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NewsHubVirtual reality, robots and drones – there’s never a dull moment at the Consumer Electronics Show, and 2017’s event offered plenty of weird scenes for attendees to take in.
Polaroid wins for the strangest booth exhibit. It assembled a giant tree-house carousel with chimps dressed as people using its Cube cameras – an extremely creepy sight.
Sharper Image’s massage parlor attracted a slew of folks looking to kick off their shoes and receive a variety of body-specific massaging tools. The booth offered hand massagers, head massagers, and full-body massage pods that rotated up and down with users inside.
It’s hard to look normal when doing anything in virtual reality, but fighting someone in a virtual landscape appears particularly strange to onlookers. Samsung offered attendees to chance to battle with an opponent through its virtual headsets.
Virtual reality also came in the form of several driving simulations from Ford and others, and some were better executed than others.
One particularly strange offering was to let attendees “meet themselves in art. ” A computer used facial recognition to match a user’s features to features in a historic painting – and the results were not always flattering.

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Intel fixes 10nm process, promises Cannon Lake this year

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NewsHubIntel’s Brian Krzanich has promised that Cannon Lake, the company’s first processor based on a 10nm manufacturing node, will launch before the year is out – two years after its original launch window. Intel has seemingly resolved its ongoing problems transitioning to a 10nm semiconductor manufacturing, promising to launch its eighth-generation Cannon Lake Core chips before the end of the year.
The move from 14nm to 10nm manufacturing nodes has not been smooth for Intel. The company’s original roadmap called for the first 10nm chips to launch in 2015, but despite considerable investment the transition did not go well. By June 2015, rumours were spreading that Intel was going to miss the launch, while in July Intel’s Brian Krzanich confirmed that the launch of the 10nm ‘Cannon Lake’ processors would have to be pushed back to some time in the second half of 2017.
The issues surrounding the 10nm transition – which were also felt during the development of the 14nm Broadwell parts, delayed to 2014 thanks to the increasingly complex physics surrounding ever-smaller components – have had a serious effect on Intel’s development process. In March last year, Intel announced it was killing off the tick-tock development cycle it had rigorously adhered to earlier in the Moore’s Law difficulty curve: Instead of releasing a revised architecture one year followed by the same architecture on a smaller process node the year after, Intel’s new approach extends the life of each node by concentrating more on architectural improvements.
Now, though, Intel is confident that it has the 10nm issues resolved – so confident, in fact, that Intel’s Brian Krzanich took to the stage at the Consumer Electronics show to promise that the first Cannon Lake parts would appear before the end of this year – despite having only just brought the 14nm Kaby Lake architecturally enhanced processor family to the open market.
The announcement brings Intel’s semiconductor manufacturing technology back on a level playing field with the like of TSMC , but former AMD manufacturing arm GlobalFoundries is claiming to be skipping 10nm in favour of jumping to 7nm with the first chips due to enter production in 2018.

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Mayer: not so much leaving Yahoo, as taking it with her?

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NewsHubMarissa Mayer is getting ready to say goodbye to Yahoo’s board, but not necessarily to the Yahoo brand.
The company said in a U. S. Securities and Exchange Commission filing Monday that it will shed almost everything that makes it Yahoo, including its name, when its deal with Verizon closes.
If you’re a Yahoo shareholder, you might notice the difference, but for Yahoo users, the consequences of Monday’s filing are minimal.
Yahoo the company has two major assets: a worldwide network of internet portals, and a 15 percent stake in Chinese internet giant Alibaba worth many times that. When a plan to sell off the Alibaba stake ran into tax complications, the company pivoted , instead striking a deal to sell its portals, its brand — almost everything but the Alibaba stake, in fact — to Verizon.
Verizon is expected to merge Yahoo’s portal activities with AOL, which it bought in 2015 .
In July, just after Verizon announced the Yahoo deal, AOL CEO Tim Armstrong told TechCrunch: “The Yahoo brand will be staying with us for a very long period of time, we’ll be investing in it. ”
He was positive about his relationship with Mayer — “I think we’ll be able to work very well together,” he said.
At the time, Mayer told CNBC’s “Squawk on the Street” that “I love Yahoo, and I want to see Yahoo into the next chapter. ”
In the months since then, Yahoo has admitted to two of the biggest data breaches ever. In September, it acknowledged that details of 500 million accounts had been stolen. In December, it said that details of 1 billion accounts were stolen in a separate incident.
News of the breaches tarnished Yahoo’s brand and the reputation of its management team and prompted reports that Verizon was seeking to renegotiate or even abandon the deal.
Monday’s filing with the SEC making preparations for the deal, though, indicates that it is still on.
Sparing us the confusion of differentiating between Yahoo the brand on the one hand, and Yahoo the company on the other, the company plans to rename itself Altaba once the deal goes through.
Once Verizon takes over the Yahoo portals and brand, Altaba’s main purpose will be as an investment vehicle for stakes in Alibaba and in Yahoo Japan, an independent company of which Yahoo only owns 35.6 percent. Most of the rest is owned by Softbank Group, the Japanese company that also owns U. S. telco Sprint and chip designer ARM.
Rules for investment companies mean Altaba will be able to operate with a smaller board after the Verizon deal closes, and so, “immediately following the closing, the size of the Board will be reduced to five directors,” from 11 today, the company said in its SEC filing on Monday. In that case, Mayer and five others will resign, it said.
Verizon declined to comment on Yahoo’s SEC filing and Yahoo itself was not immediately available to answer queries. AOL’s Armstrong, though, appears to still be positive about his working relationship with Mayer. In December, Armstrong told Business Insider that while he could not speak for Mayer, he wanted her to continue to develop Yahoo’s activities at Verizon: “Hopefully, as we go forward, Marissa will play a role in getting Yahoo to the next generation of what Yahoo is going to be,” he said.
So really, it’s not Yahoo, but Altaba, that Mayer would be leaving. And she’ll be taking most of Yahoo with her.

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Clare Hollingworth, the reporter who broke news of World War II, dies at 105

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NewsHubClare Hollingworth, a British war correspondent who was the first to report the Nazi invasion of Poland that marked the beginning of World War II, died in Hong Kong on Tuesday. She was 105.
The Foreign Correspondents’ Club of Hong Kong announced her death, calling her a beloved member with a remarkable career, including “the scoop of the century.”
A determined journalist who defied gender barriers and narrowly escaped death several times, Hollingworth spent much of her career on the front lines of major conflicts, including in the Middle East, North Africa and Vietnam, working for British newspapers. She lived her final four decades in Hong Kong after being one of the few Western journalists stationed in China in the 1970s.
She won major British journalism awards, including a “What The Papers Say” lifetime achievement award, and was made an Officer of the Order of the British Empire by Queen Elizabeth II. Former British Prime Minister Ted Heath and former Hong Kong Gov. Chris Patten were fans of Hollingworth, while various British generals wrote about her fondly.
The scoop that launched her career came in late August 1939, when she was a 27-year-old rookie reporter in southern Poland, barely a week into her job with Britain’s Daily Telegraph.
The border was closed to all but diplomatic vehicles, so she borrowed a British consulate official’s car to drive into German-occupied territory. She saw tanks, armored cars and artillery massing.
She recounted in her autobiography that burlap screens beside the road, “constructed to hide the military vehicles, blew in the wind, thus I saw the battle deployment.”
“I guessed that the German Command was preparing to strike to the north of Katowice and its fortified lines and this, in fact, was exactly how they launched their invasion in the south.”
Returning to Poland, she filed her story, but her name was not on the byline — a common practice for newspapers in those days.
She scored another scoop when the Nazis launched their invasion three days later on Sept. 1.
Her first call was to the British Embassy in Warsaw, but the official she talked to didn’t believe her.
“ ‘Listen!’ I held the telephone out my bedroom window. The growing roar of tanks encircling Katowice was clearly audible,” she recounted in her autobiography. “ ‘Can’t you hear it?’ ”
She then called the Telegraph’s Warsaw correspondent, who dictated her story to London.
As the Nazis advanced, Hollingworth scrambled to get out of Poland, sometimes sleeping in cars, eventually making her way to Romania.
Hollingworth was born Oct. 10, 1911, to a middle-class family in the village of Knighton in Leicestershire, England. Her father ran a boot factory founded by her grandfather. She took brief courses in Croatian at Zagreb University, international relations in Switzerland and Slavonic studies in London. She worked as a secretary and then at a British refugee charity in Poland while writing occasional articles about the looming war in Europe. Friends influenced her decision to focus on journalism rather than politics.
The Daily Telegraph’s editor gave her a job as a stringer and sent her to Poland, partly because of her work with refugees in that country, according to her great-nephew, Patrick Garrett.
During her five months with the charity, Hollingworth played an important role in helping an estimated 2,000 to 3,000 refugees flee from the Nazis to Britain by arranging visas for them, a fact that Garrett unearthed in research for his 2016 biography of his great-aunt, “Of Fortunes and War.”
Though she carved out a career in what was then a male-dominated field, Garrett said she looked back on her achievements matter-of-factly.
“She would never regard herself as a feminist,” Garrett said. She hated when women were given special treatment because it made women a “hassle,” which made it harder for other female journalists trying to cover wars, Garrett said.
“She thought that everyone should be treated the same. She hated it when women wasted time on makeup or getting their hair done,” Garrett said.
After the Polish invasion, Hollingworth covered the Romanian Revolution and hostilities in North Africa. When Allied forces captured Tripoli in 1943, British Field Marshal Bernard Montgomery ordered her back to Cairo because he didn’t want women around. So she instead got herself accredited with U. S. forces in Algeria.
Later she reported on the fall of the Balkan states to communism, and on Cold War espionage, including the case of Kim Philby, a British journalist and Soviet double agent.
Hollingworth wrote for many publications in her career, including the Economist, the Manchester Guardian and the Daily Express.
Hollingworth was close to danger for decades. In 1946, she was standing 300 yards from the King David Hotel in Jerusalem when it was destroyed by a bomb planted by militant Zionists that killed nearly 100 people.
While covering the Algerian war for independence in 1962, Hollingworth defied members of a French far-right group who rounded up foreign journalists and threatened some of them with execution.
“I was extremely annoyed at this treatment, and I told their commander in French, ‘Go away at once, monsieur, or I will have to hit you over the head with my shoe, which is all I have.’ ”
The commander pushed her aside, grabbed another British journalist and dragged him out the front door of their hotel. Hollingworth led the other reporters outside in pursuit of their colleague, who was thrown to the ground. The gunmen released the safety catches on their guns, and the reporters dove for cover, but they drove off without shooting.
Covering the Vietnam War, Hollingworth flew aboard U. S. military aircraft on supply runs and bombing missions.
Hollingworth became the Telegraph’s first resident China correspondent when the newspaper sent her to the capital then known as Peking in 1973, a year after U. S. President Richard Nixon’s landmark visit that eventually led to formal ties between the U. S. and China.
She moved to Hong Kong in 1981. She had intended to stay temporarily as she wrote a book about Mao Zedong, but decided to stay to watch the negotiations over Britain’s return of Hong Kong to China in 1997 and never left.
Hollingworth wrote articles for the International Herald Tribune and Asian Wall Street Journal well into her 80s. She was known for visiting the Foreign Correspondents’ Club every day, where her domestic helpers read newspapers to her because of her failing eyesight, and where friends and admirers helped her celebrate her 105th birthday with cake.
Tonight, President Obama returns to Chicago to give a prime-time farewell address. Attorney general nominee Sen. Jeff Sessions is in the hot seat today. A storm that hit Northern California toppled the Pioneer Cabin Tree. Who should discipline police officers?
Raw video of an attempted murder suspect leading police on a chase on the 405 Freeway Monday night.
Rescue crews were searching the Dominguez Channel in the Gardena area Monday morning after a woman reported her boyfriend had been washed away after entering the channel.
Meryl Streep accepted the Cecil B. DeMille award at the 2017 Golden Globes Sunday Jan. 8.
“La La Land” was the big winner at the Golden Globes , what values does Hollywood promote? , storms have slammed Northern California , Thomas Barrack’s latest gig is planning the president-elect’s inauguration .
“La La Land” was the big winner at the Golden Globes , what values does Hollywood promote? , storms have slammed Northern California , Thomas Barrack’s latest gig is planning the president-elect’s inauguration .

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History Lesson: Chinese Professor’s Mao Remarks Get Him Fired

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NewsHubA Chinese professor who posted critical remarks about Mao Zedong on social media is the latest to find out that, under President Xi Jinping , taking issue with the Communist Party’s past brings trouble.
Shandong Jianzhu University last week fired Deng Xiangchao, a professor in the school’s art institute, for his “erroneous remarks” on the Weibo social-media service. In the aftermath of the postings, he was vilified by protesters and online, with some calling him “the People’s Public Enemy.”
Mr. Deng’s posts last month hit at a part of Mao’s legacy that has been tricky for the Communist Party to address: the deaths associated with the revolutionary leader’s policies and campaigns. “If he’d died in 1945, China would have seen 6 million fewer killed in war. If he’d died in 1958, 30 million fewer would’ve starved to death,” said one post. “It wasn’t until 1976 when he finally died that we at last had food to eat. The only correct thing he did was to die.”
In firing Mr. Deng, university leaders noted the outcry his posts had created and reported the issue to provincial authorities, said a propaganda officer with the school. A notice posted by the government-backed university on its internal website said the nature of Mr. Deng’s posts was vile and their influence was very bad.
Mr. Deng wasn’t reachable for comment. His Weibo account appears to have been deleted.
His punishment fits with more aggressive policing of dissent under President Xi, with a renewed sensitivity to criticisms of the party’s past, particularly under Mao.
“There’s been a significant tightening of what people can say, particularly in public. To speak about historical figures like Mao has become more sensitive than it was five or 10 years ago,” said Kerry Brown, director of the Lau China Institute at King’s College London.
“The party is demanding respect and that means respecting the history of the party,” he said. “Obviously Mao is important to that history. You can’t have a pick and mix attitude.”
Mao’s radical policies resulted in mass deaths and waves of political persecution. His Great Leap Forward drive to increase harvests led to widespread famine and more than 20 million deaths at the lower estimates of Chinese researchers; more than 30 million is a widely accepted toll.
Those episodes are rarely allowed full public discussion. In addressing Mao’s legacy in the early 1980s, his successor Deng Xiaoping declared him “70% right and 30% wrong.”
Still, the party embraces Mao as a symbol of its legitimacy, hanging his portrait in Tiananmen Square and putting his face on every banknote. Despite the fact that his father was purged in the Cultural Revolution, Mr. Xi has declared it unacceptable to critically dismiss Mao’s 30-year reign and delink it from the country’s recent decades of rapid development.
Last year, Chinese authorities purged top editorial staff at Yanhuang Chunqiu, a reform-minded journal that often featured searching articles on the Cultural Revolution and other events in party history. Censors have also shuttered dozens of history-themed social media accounts for spreading “unhealthy information.”
After a surreptitiously videotaped lecture showing a respected academic at the party’s elite training academy criticizing Mao went viral last summer, a backlash ensued. Wang Changjiang said in the videotape that Mao had been unable to satisfy people’s basic wants of food and clothing. Shortly thereafter, Mr. Wang stepped down from his position as the director of a research department at the Central Party School, citing reasons of age.
The year prior, a prominent television host was suspended after a video of him mocking Mao at a private dinner surfaced online.
In the latest instance, reposting Professor Deng’s remarks also caused repercussions for a television employee in the central city of Luohe. Liu Yong was suspended from his advertising job, according to Luohe Television’s official Weibo account, for “making erroneous comments and distorting the truth” on his personal Weibo account. Reached by phone, a colleague said that Mr. Liu had recirculated material from Mr. Deng’s Weibo account on his own personal Weibo account, which has since been suspended.

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Xi to be first Chinese leader to attend Davos World Economic Forum

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NewsHubBEIJING/GENEVA: President Xi Jinping this month will become the first Chinese head of state to attend the World Economic Forum (WEF) in Davos, which this year will dwell on the rising public anger with globalisation and the coming U. S. presidency of Donald Trump.
Xi will take centre stage at the Jan. 17-20 forum with China presenting itself as a champion of globalisation.
The Chinese Foreign Ministry on Tuesday confirmed Xi’s widely expected attendance at the annual gathering of global political leaders, CEOs and celebrities in the Swiss Alps.
Davos will end just as Trump takes office, having won the White House in part with promises to pull the United States out of international trade deals and hike tariffs against China and Mexico in a protectionist campaign he says will help bring back industries and jobs to America.
WEF executive chairman Klaus Schwab said he expected Xi to show how China would take a “responsive and responsible leadership role” in global affairs at a turning point in history, with the world needing new concepts to face the future.
“Every simplified approach to deal with the complex global agenda is condemned to fail. We cannot have just populist solutions,” Schwab told a news conference in Geneva, referring to the rising anti-globalisation tide epitomized by Trump’s victory and Britain’s vote last year to exit the European Union.
The Chinese president will be in Switzerland from Jan. 15-18 for a state visit and to attend the Davos meeting, Foreign Ministry spokesman Lu Kang told a regular press briefing.
He will also visit the United Nations offices in Geneva, and the offices of the World Health Organization and the International Olympic Committee, Lu said.
Other global leaders, including WEF regular German Chancellor Angela Merkel and Canadian Prime Minister Justin Trudeau, will not be in Davos this year.
European Commission President Jean-Claude Juncker was also absent from the line-up published on Tuesday, but there were many presidents, prime ministers and central bankers among the 3,000 participants, along with 1,800 executives from 1,000 companies.
The United States will be represented by Vice President Joe Biden and Secretary of State John Kerry, days before they leave office, and “someone from the transition team representing the new (Trump) administration”, Schwab said.
Xi led a forum of Asia-Pacific leaders in Peru in November in vowing to fight protectionism, just days after Trump won the U. S. election having pledged to pull out of the 12-nation Trans-Pacific Partnership (TPP) trade deal.
Foreign businesses in China, however, have long complained about a lack of market access and protectionist Chinese policies. These include a Made in China 2025 plan that calls for a progressive increase in domestic components in sectors such as advanced information technology and robotics.

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Taiwan's president calls China a ‘threat,’ predicts turbulent 2017

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NewsHubTaiwan’s President Tsai Ing-wen on Saturday said China is becoming a growing threat to the self-ruled island and predicted a volatile but pivotal 2017.
“The Beijing leadership has, step by step, backed onto an old track to polarize, pressure and even threaten and intimidate Taiwan,” Tsai said. “We hope that this is not Beijing’s adoption of a policy and want to remind it that such moves have hurt Taiwanese people’s feelings and affected stability across the Taiwan Strait.”
Tsai’s comments, at a year-end news conference, came after China sent its first aircraft carrier and five other warships through waters near Taiwan this week. The island has also suffered the loss of diplomatic alliances in Africa to China this year and, since April, a more than 30% drop in tourism from the Chinese mainland.
China has claimed sovereignty over Taiwan since the Chinese civil war in the 1940s and opposes any moves in Taiwan or abroad to legitimize its self-rule.
President-elect Donald Trump ‘s surprise phone call with Taiwan’s president left many in China reeling over a perceived assault on the country’s sovereignty and questioning their assumptions about America’s future leader.
Although Trump repeatedly denounced China’s trade policies as unfair during…
President-elect Donald Trump ‘s surprise phone call with Taiwan’s president left many in China reeling over a perceived assault on the country’s sovereignty and questioning their assumptions about America’s future leader.
Although Trump repeatedly denounced China’s trade policies as unfair during…
Tsai has irritated China since taking office May 20 by rejecting Beijing’s conditions for talks that the Communist Party leadership hopes could someday lead to unification of the two sides. 
Tsai opposes these conditions because they would unite the sides under China. Most Taiwanese prefer self-rule, according to government surveys of public opinion.
Tsai also irked China this month by making a 10-minute phone call to President-elect Donald Trump.
The United States has been an informal ally of and arms seller to Taiwan. But until that day, no American president or president-elect is believed to have spoken directly with a Taiwanese leader since the U. S. recognized the mainland government and cut ties with Taiwan in 1979.
Tsai said Saturday that Taiwan would not meet Beijing with “resistance”  but rather “maintain our status of peace and stability.” 
On Saturday, she travels to four Central American countries: El Salvador, Guatemala, Honduras and Nicaragua. China has asked the U. S. to bar Tsai from transiting through U. S. cities on her way to the region and back.
The loss of Gambia and Sao Tome and Principe as allies has raised concern in Taiwan that China might use development aid as an inducement to other countries to switch sides.
Taiwan will push for closer ties with India and other countries in Southeast Asia that recognize China over Taiwan, Tsai said Saturday. 
“In 2017, our society is going to face some turbulence and face some uncertainties,” she warned. “It’s going to test our whole national security team, as well as the whole government’s ability to handle change.”
But, she added, “We need to face this matter calmly.” If China and Taiwan share a “rational” approach, she said, some problems could be worked out.
“It is not impossible that there is room for creativity.”
Tonight, President Obama returns to Chicago to give a prime-time farewell address. Attorney general nominee Sen. Jeff Sessions is in the hot seat today. A storm that hit Northern California toppled the Pioneer Cabin Tree. Who should discipline police officers?
Raw video of an attempted murder suspect leading police on a chase on the 405 Freeway Monday night.
Rescue crews were searching the Dominguez Channel in the Gardena area Monday morning after a woman reported her boyfriend had been washed away after entering the channel.
Meryl Streep accepted the Cecil B. DeMille award at the 2017 Golden Globes Sunday Jan. 8.
“La La Land” was the big winner at the Golden Globes , what values does Hollywood promote? , storms have slammed Northern California , Thomas Barrack’s latest gig is planning the president-elect’s inauguration .
“La La Land” was the big winner at the Golden Globes , what values does Hollywood promote? , storms have slammed Northern California , Thomas Barrack’s latest gig is planning the president-elect’s inauguration .

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Alibaba to help China retailer Intime go private in $2.6 billion deal

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NewsHubAlibaba Group Holding Ltd. said it would team up with the founder of China’s Intime Retail (Group) Co. to take the department-store operator private, as the e-commerce giant seeks to extend its online dominance into physical stores.
The deal requires approval from Intime shareholders and from a court in the Cayman Islands, where Intime is incorporated, an Alibaba spokeswoman said.
An expanded version of this story can be found at WSJ.com
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